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We have been investigating the molecular and cellular components of innate and acquired immunity, which contribute to the development of placental malaria in pregnant women. These studies may unveil pharmacological targets to promote the fetal viability and protection mechanisms valuable in abortion and stillbirth prevention. The translation of this research will benefit from the availability of collections of the human placenta from Amazonia, as well as studies of cohorts with pregnant women conducted by our group in an endemic area for malaria in Brazil.